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Overall, taken together with previous efforts, these insights encouragingly designate FOXO4-TP53 as a noteworthy complex not only for drug discovery studies combatting age-related diseases but also for our understanding of interactions of transcription factors

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For example, rat liver cystathionine γ-lyase catalyzes (1) the formation of S -mercapto-l-cysteine from l-cystine (Cavallini et al., 1960), (2) β-elimination of alkane thiols from several nonhalogenated cysteine S -conjugates containing alkyl groups attached to the sulfur (Tomisawa et al., 1988), and (3) β-elimination of alkyl/allyl thiols/persulfides from various alkyl/allyl cysteine S -conjugates present in garlic extracts (Cooper and Pinto, 2005, Pinto et al., 2006)