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Magnetic resonance spectroscopy (MRS) studies further substantiate the evidence of metabolic disturbances: in ME/CFS patients, brain lactate concentrations and the choline/creatine ratio are significantly elevated, indicating increased anaerobic glycolysis and altered membrane phospholipid metabolism, both of which are linked to neuroinflammation and mitochondrial oxidative stress (155)

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Understanding the reasons behind this swelling can help individuals manage their expectations and employ effective strategies for reducing discomfort and promoting a smoother healing process