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On the arginine side, the formation of the six-membered ring probably arises from a nucleophilic attack on the guanidinium C ζ atom of arginine by the C2 ene-activated carbon of glutaraldehyde (formally represented as a carbanion in Fig

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16 It has been shown that chronic stress induces dysfunction of hypothalamic–pituitary adrenal (HPA) axis leading to elevation of cortisol which causes IR and abdominal adiposity