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The locus coeruleus is involved in opioid addiction development: in mice, hypothalamic hypocretin innervation increases after morphine administration, correlated with an increase in tyrosine hydroxylase expression (the enzyme that catalyzes the rate limiting step in this synthesis of catecholamines)

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Expression values of IFI27, IFI44L, IFIT1, ISG15, RSAD2 , and SIGLEC1 were used to calculate an “IFN score” for each individual and according to an established approach to minimize inter-laboratory variability in IFN signature analysis (41)