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While the role of these tissues in the metabolic clearance of bilirubin is starting to be understood, we can speculate that UGT1A1 expression in the brain might exhibit protective effects against the accumulation of unconjugated bilirubin from bilirubin-induced brain damage

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Mice with global loss or mutation of Bbs genes, which are used as a model of BBS, are obese and have leptin resistance 62