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(2017) developed a self-assembling nano-complex constituted of a DOTMA:DOPE liposome, an epithelial targeting peptide and siRNA (small interfering RNA, which represents an attractive approach for the treatment of several pulmonary diseases characterized by an over-expression of genes) against the α-subunit of epithelial sodium channel (ENaC), thus modulating sodium hyperabsorption and helping to restore the mucus hydration and the airway clearance