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This study uncovers a novel mechanism underlying tinnitus and lays the groundwork for the development of therapeutic and preventive strategies

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DNA-PK functions redundantly with SMG1 to activate NRF2 under mild oxidative stress Because phosphorylation of the SQ motifs at NRF2-S13 and -S40 is critical for NRF2 accumulation, we next examined whether other phosphatidylinositol 3-kinase–related kinases (PIKKs) function redundantly with SMG1

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