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The majority of cell surface receptors are glycosylated/sialylated, and hyposialylation of muscle glycoproteins is thought to be responsible for muscle deterioration in mouse models of GNE myopathy 17,18,19,20

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Abbreviations AAS: Antibiotic antimycotic solution α-GST: Alpha-glutathione s-transferase ALT: Alanine aminotransferase ASGPR1: Asialoglycoprotein receptor 1 CD206: Mannose receptor CD32b: Fc fragment of IgG receptor IIb CYP3A4: Cytochrome P450 3A4 DILI: Drug-induced liver injury DMSO: Dimethyl sulfoxide IL: Interleukin KCs: Kupffer cells LDH: Lactate dehydrogenase LPS: Lipopolysaccharide LSECs: Liver sinusoidal endothelial cells LVX: Levofloxacin mBCI: Monochlorobimane MDMs: Monocyte-derived macrophages PBS: Phosphate buffered saline ROS: Reactive oxygen species RT: Room temperature TNF-α: Tumor necrosis factor-alpha TVX: Trovafloxacin VPM: Vascular perfusion medium References Stevens, J

This process not only aids in fat metabolism but also enhances endurance and performance